Cause, symptoms and treatment of hair loss

Cause, symptoms and treatment of hair loss

Alopecia The hair is thought to be a major component of an individual’s general appearance. It is a physical expression of personality and social role and for many, it is central to feelings of attractiveness and self-esteem. Alopecia (baldness or hair loss) has negative attributes and can bring about low self esteem in affected individuals [1, 2]. What is Alopecia? Alopecia (also known as baldness or hair loss) refers to loss or lack of hair on part of or the entire scalp and in some cases, other parts of the body. Hair loss can be temporary or permanent and can affect people of all ages. Although alopecia can occur anywhere on the body, it is most distressing when it affects the scalp. It can range from a small bare patch, which is easily masked by hairstyling to a more diffuse and obvious pattern [3, 4]. Causes of Alopecia Causes of alopecia include,

1. Genetics

2. Prolonged fever

3. Hormonal changes, such as childbirth, use of birth control pills or thyroid disease

4. Treatment for cancer, such as chemotherapy

5. Continual hair pulling or scalp rubbing

6. Burns or radiation therapy

7. Emotional or physical stress

8. Ringworm of the scalp (Tinea capitas)

9. Some prescription medicine

(To mention a few)

Types of Alopecia

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The different types of alopecia associated with loss of hair on the scalp include,

1. Androgenetic alopecia (Genetic hair loss)
Androgenetic alopecia, also known as male pattern hair loss is a major problem affecting men and is such that by the age of 50, up to 50% of men who are genetically predisposed will be affected. It is characterised by progressive, patterned hair loss from the scalp and its prerequisites are a genetic predisposition and sufficient circulating androgens (steroid hormone such as testosterone or androsterone, which promotes male characteristics). According to Sinclair (1998) every Caucasian male possesses the autosomal inherited predisposition, and as such, 96% lose hair to some degree. Sinclair also mentions that Caucasian men are four times more likely to develop premature balding than Black men. Hair loss does not usually start until after puberty with an extremely variable rate of progression [1, 5].

The condition is also fairly common in women and is referred to as female pattern hair loss. In women, “it is characterised by a diffuse reduction in hair density over the crown and frontal scalp with retention of the frontal hairline” [6]. Birch et al (2002) make mention of the fact that in some women, the hair loss may affect a small area of the frontal scalp whilst in others the entire scalp is involved. In advanced female pattern hair loss, the hair becomes very sparse over the top of the scalp bit a rim of hair is retained along the frontal margin. The vertex (crown or top of the head) balding seen in men is rare in women; however, a female pattern of balding is not uncommon in men [6]. The androgen-dependent nature or the genetic basis of female pattern hair loss has not been clearly established, although a study carried out by Sinclair et al (2005) showed that androgens play an important role in the development of female pattern hair loss.

2. Alopecia areata (AA)
Alopecia areata (AA) is a common, immune-mediated, nonscarring form of hair loss, which occurs in all ethnic groups, ages (more common in children and young adults), and both sexes, and affects approximately 1.7% of the population [8, 9]. Alopecia areata is unpredictable and patients usually present with several episodes of hair loss and regrowth during their lifetime. Recovery from hair loss may be complete, partial, or nonexistent. It is thought that 34 to 50% of patients with AA will recover within a year whilst 15 to 25% will progress to total loss of scalp hair or loss of the entire scalp and body hair where full recovery is unusual [8, 11]. It usually presents as a single oval patch or multiple confluent patches of asymptomatic (without obvious signs or symptoms of disease), well circumscribed alopecia with severity ranging from a small bare patch to loss of hair on the entire scalp. Frequent features of AA patches are exclamation mark hairs, which may be present at its margin; the exclamation mark hairs are broken, short hairs, which taper proximally. The hair loss from AA may be the only obvious clinical abnormality or there may be associated nail abnormalities. Other less common associated diseases include thyroid disease and vitiligo [4, 10, 11].

Clinical presentation of AA is subcategorised based on the pattern and extent of the hair loss. If categorised according to pattern, the following are seen;
a. patchy AA, which consists of round or oval patches of hair loss and is the most common,
b. reticular AA, which is a reticulated (networked) pattern of patchy hair loss,
c. ophiasis band-like AA, which is hair loss in parieto-temporo-occipital scalp (middle-side-back of scalp),
d. ophiasis inversus, which is a rare band-like pattern of hair loss in fronto-parieto-temporal scalp (front-middle-side of scalp), and
e. diffuse AA, which is a diffuse decrease in hair density.
[Taken from Shapiro J and Madani S, 1999]

If categorised according to the extent of involvement, the following are seen;
a. alopecia areata, which is the partial loss of scalp hair,
b. alopecia totalis, which is 100% loss of scalp hair, and
c. alopecia universalis, which is 100% loss of body hair.
[Taken from Shapiro J and Madani S, 1999]

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3. Telogen Effluvium (TE)
Telogen effluvium is an abnormality of hair cycling, which results in excessive loss of telogen (resting phase of hair cycles) hairs and is most common in women. Women with this disorder would usually notice an increased amount of loose hairs on their hairbrush or shower floor. Daily loss of hair may range from 100 to 300 hairs. It is thought that TE may unmask previously unrecognised androgenetic alopecia. The most common underlying cause of TE is stress; other causes include certain diseases such as thyroid and pituitary diseases, some medication and child birth, to mention a few. In many cases however, no cause can be found. TE usually begins two to four months after the causative event and can last for several months [4, 12]. Unlike some other hair loss conditions, TE is temporary and hair regrowth is possible [4]. Telogen effluvium presents in about three forms;
a. Acute telogen effluvium, where shedding of hair is expected to cease within 3 to 6 month
b. Chronic diffuse telogen hair loss, which is telogen hair shedding persisting longer than 6 months. Common causes include thyroid disorders, acrodermatitis, profound iron deficiency anaemia, and malnutrition.
c. Chronic telogen effluvium (CTE) is the most common cause of hair loss in women, affecting 30% of females, between the ages of 30 and 60 years old, in the UK. CTE is such that there is a relative change in the proportion of growing to resting hair and in most cases, excessive shedding of hair has been present for at least 6 months. According to Rushton et al (2002) studies have shown that 95% of CTE cases arise from a nutritional imbalance involving the essential amino acid L-lysine and iron. Other common causes of CTE include drugs, thyroid disease and childbirth [1, 11].

4. Cicatricial alopecia (scarring alopecia)
Circatricial alopecia, also known as scarring alopecia, refers to a group of rare hair disorders resulting from a condition that damages the scalp and hair follicle. They present as areas of hair loss in which the underlying scalp is scarred, sclerosed, or atrophic. In other words, the disorders destroy the hair follicle and replace the follicles with a scar tissue consequently causing permanent hair loss. Conditions associated with circatricial alopecia include autoimmune diseases such as discoid lupus erythematosus, scalp trauma, infections such as tuberculosis and syphilis, and radiation therapy. Circatricial alopecia affects both adults and children, and may present as primary or secondary circatricial alopecia [4, 13].

5. Chemotherapy-related alopecia
Alopecia caused by chemotherapy may vary from slight thinning of the hair to complete baldness. The extent of alopecia depends on the choice of drugs and its dose. Drugs which cause severe alopecia include methotrexate, vinblastine, adriamycin, ifosphamide, vincristine, and taxoids to mention a few. When drugs are used in combination, which is usually the case with many treatment regimes, the incidence and severity of alopecia can be greater than usual. According to Randall et al (2005) “chemotherapy-related alopecia has been rated by patients as one of the most severe, troublesome and traumatic chemotherapy-related side effects”. Hair loss due to chemotherapy is not permanent and as such, the hair will grow back once treatment has ended [14].

6. Traumatic alopecia
This is usually a very common cause of hair loss in women of some ethnic backgrounds (particularly women of African/Caribbean descent). It is caused as a result of hair grooming techniques by the use of hair reshaping products such as relaxers, straighteners, hot combs, foam rollers and permanent wave products, as well as hair braiding methods. These techniques damage hair follicles over time [15]. Traumatic alopecia is divided into three categories;
a. Traction alopecia, which results from persistent pulling of the hair by tight rollers, tight braiding or ponytails. The use of blow-dryers, vigorous combing or brushing and bleaching of the hair can also contribute to hair breakage. Thinning begins above the ears and the forehand, and if the causative styling methods are not stopped, irreversible hair loss can result as the hair follicles are destroyed [15, 16].
b. Chemical alopecia, which results from the use of commercial relaxer and styling products. These products contain chemicals such as thioglycolates, which create curls or straighten the hair by destroying the disulphide bonds of keratin. Apart from curling or straightening the hair, these chemicals may have irritant effects on the scalp, which can result in hair shaft damage, inflammation of the scalp and loss of hair roots. All these can lead to irreversible damage of the hair follicles [15, 16].
c. Hot-comb alopecia, also known as follicular degeneration syndrome, results from the excessive use of pomades with a hot comb or iron, which leads to a gradual destruction of hair follicles. When pomade comes in contact with a hot comb or hot iron, it liquefies and drips down the hair shaft into the follicle. This results in chronic inflammatory folliculitis, which can lead to scarring alopecia and consequently permanent hair loss. Thinning usually begins at the crown and then spread evenly throughout the head. The condition is irreversible [15, 16].

Common baldness/hair loss myths Several myths about hair loss exist, some serious, others not so serious. These myths include;

1. Male pattern baldness (as well as female pattern baldness) is inherited from the mother’s side of the family: This is not true as studies have been conducted, which conclusively suggest that it can come from either side of the family.

2. Cutting the hair can make it grow faster and stronger. When hair grows longer, it is worn down by normal wear and tear and as such gets slightly thinner around the diameter of the shaft. Cutting the hair cuts it back to where there is less wear and tear and subsequently the hair shaft is slightly thicker, giving the impression that cutting the hair makes it thicker. It would also not grow faster as hair grows almost exactly half an inch per month regardless of whether it is cut or not.

3. Wearing a hat can cause hair loss. This can only happen if the hat is prohibitively tight as any form of pulling or tightening of the hair can have some effect on hair loss; however, wearing a hat on its own cannot cause hair loss.

4. Towel drying your hair rigorously will make your hair fall out faster. This can only occur if the hair was due to fall out anyway; however you won’t be promoting additional hair loss by towelling rigorously

5. Rubbing curry on the head will help hair loss. Not only will it not work, you’re likely to smell afterwards as well.

6. Split ends can be repaired. This is not true as split ends cannot be repaired and should be cut off immediately to avoid them splitting higher and causing more damage to the hair.

7. Having a cow lick the top of your head can help hair loss. This would not help your hair loss, but might be entertaining to watch.

8. Standing on your head, or hanging upside down will increase the blood flow to the head and reduce hair loss. It is true that standing on your head or hanging upside down will increase the blood flow to the head; however, it won’t do anything to hair loss.

Quality of life and psychological aspects The hair constitutes an integral part of our self and our identity and as such hair loss may cause a wide range of psychological problems related to our identity. Alopecia in itself has few physically harmful effects; however, it may lead to problems such as high levels of anxiety, social phobia, paranoid disorder and serious depressive episodes. The extent of alopecia is one of the predictors of the severity of psychological distress [12, 17].

There is an important link between hair and identity, especially for women. Feminity, sexuality, attractiveness, and personality, as reiterated by Hunt et al (2005), are symbolically linked to a woman’s hair and as such hair loss can seriously affect self esteem and body image. Hunt et al (2005) also stated that about 40% of women with alopecia have had marital problems as a consequence whilst about 63% claim to have had career related problems NETQUOTEVAR:18.

Psychological problems can also be experienced by children affected by alopecia.

Management of Alopecia

Alopecia can be managed in different ways, depending on type and severity. The various methods of management include;

1. Medical treatment such as the use of topical minoxidil, oral finasteride, topical tretinoin, exogenous estrogen, spironolactone and anti-androgens for androgenetic alopecia. The type of treatment and dose may vary depending on gender and age (i.e. adult or children).

2. Medical treatment such as the use of immunomodulatory agents (e.g corticosteroids, 5% minoxidil, and anthralin cream) and topical immunotherapeutic agents (e.g dinitrochlorobenzene and diphenylcyclopropene) for alopecia areata.

3. For hair loss caused by telogen effluvium, the underlying cause is usually treated first.

4. Cicatricial alopecia is sometimes managed using both systemic and topical therapy, this includes the use of hydroxychloroquine, topical immunomodulators (e.g tacrolimus and pimecrolimus), intralesional injections of triamcinolone, mycophenolate mofetil, cyclosporine, and isotretinoin, to mention a few.

5. When hair loss is extensive, wigs may be worn; there is also the option of hair transplantation (using minigrafts).

6. To reduce the risk of traumatic alopecia, techniques for hair grooming should be used with caution bearing in mind the sensitivity of the scalp and hair follicles. Discontinuance of styling practices may result in an abatement of hair loss and partial hair growth; this depends on the length of insult to the roots. Complete re-growth is possible if hair loss is managed early NETQUOTEVAR:15.

7. The use of laser phototherapy, which offers a respite from drugs, chemicals, lotions, visits to hospitals, dermatologist centres and surgery, is non-toxic, safe and can be used at home (see our new Hairbeam Phototherapy product).